Strand-coordinated mutagenesis Topography Assessment could not be performed for strand-coordinated mutagenesis as the amount of satisfying our constraints was inadequate or this signature wasn't nevertheless analysed.
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Hence, we will assign an expected probability for the provided mutation being created for every signature. This model assumes a uniform signatures activity eventually.
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In addition to The only base signature discussed to this point, it is thought that colibactin from pks+ E.coli also induces quick deletions at T homopolymers9,thirteen. We investigated no matter if quick T deletions at T homopolymers happened in both ordinary and cancer crypts of our dataset. The short T-del signature was even more obvious than The one base pks+ signature (SPS7/SBS88) and will be present in almost all samples (Fig.
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